Spot detectoion at the single cell level: A computational approach to analyse ifish spots in consecutive sections of heterogeneous neuroblastoma tumors

Autoren Magdalena Ambros
Maria Berneder
Lukas Fischer
Marco Feuerstein
Allan Hanbury
Inge M. Ambros
Peter F. Ambros
Sabine Taschner-Mandl
Editoren
Titel Spot detectoion at the single cell level: A computational approach to analyse ifish spots in consecutive sections of heterogeneous neuroblastoma tumors
Typ sonst
Ort 15th YSA PhD Symposium, Vienna, Austria, June 113-14, 2019.
Monat June
Jahr 2019
Seiten Poster
SCCH ID# 19040
Abstract

Interphase-fluorescence in situ hybridization (iFISH) is a robust and powerful method to detect chromosomal aberrations and rearrangements at single-cell resolution. Automated image analysis methods, based on iFISH spot detection at the single cell level, could help to better describe tumor heterogeneity. However, methods to segment spot- and nuclear images and to analyze spatially resolved single-cell features in tissue sections are still missing.