Investigation of genetic tumor heterogeneity using correlated images of H&E and fish stained consecutive tissue sections

Autoren Magdalena Ambros
Maria Berneder
Lukas Fischer
Marco Feuerstein
Allan Hanbury
Inge M. Ambros
Peter F. Ambros
Sabine Taschner-Mandl
Editoren
Titel Investigation of genetic tumor heterogeneity using correlated images of H&E and fish stained consecutive tissue sections
Typ sonst
Organisation COMULIS & BioImaging Austria/CMI Conference, Vienna, Austria, November 21-22, 2019.
Monat November
Jahr 2019
SCCH ID# 19095
Abstract

Interphase-fluorescence in situ hybridization (iFISH) is a robust and powerful method to detect chromosomal aberrations and rearrangements at single-cell resolution. Automated image analysis methods, based on iFISH stainings applied to consecutive tissue sections, could help to better describe tumor heterogeneity. However, methods to analyze spatially resolved single-cell features in tissue sections are still missing.