Investigation of genetic tumor heterogeneity using correlated images of H&E and fish stained consecutive tissue sections
Inge M. Ambros
Peter F. Ambros
|Titel||Investigation of genetic tumor heterogeneity using correlated images of H&E and fish stained consecutive tissue sections|
|Organisation||COMULIS & BioImaging Austria/CMI Conference, Vienna, Austria, November 21-22, 2019.|
Interphase-fluorescence in situ hybridization (iFISH) is a robust and powerful method to detect chromosomal aberrations and rearrangements at single-cell resolution. Automated image analysis methods, based on iFISH stainings applied to consecutive tissue sections, could help to better describe tumor heterogeneity. However, methods to analyze spatially resolved single-cell features in tissue sections are still missing.