Investigation of genetic tumor heterogeneity using correlated images of H&E and fish stained consecutive tissue sections

M. Ambros, M. Berneder, L. Fischer, M. Feuerstein, A. Hanbury, I. Ambros, P. Ambros, S. Taschner-Mandl. Investigation of genetic tumor heterogeneity using correlated images of H&E and fish stained consecutive tissue sections. 11, 2019.

Autoren
  • Magdalena Ambros
  • Maria Berneder
  • Lukas Fischer
  • Marco Feuerstein
  • Allan Hanbury
  • Inge M. Ambros
  • Peter F. Ambros
  • Sabine Taschner-Mandl
TypSonstiges
OrganisationCOMULIS & BioImaging Austria/CMI Conference, Vienna, Austria, November 21-22, 2019.
Monat11
Jahr2019
Abstract

Interphase-fluorescence in situ hybridization (iFISH) is a robust and powerful method to detect chromosomal aberrations and rearrangements at single-cell resolution. Automated image analysis methods, based on iFISH stainings applied to consecutive tissue sections, could help to better describe tumor heterogeneity. However, methods to analyze spatially resolved single-cell features in tissue sections are still missing.