Spot detectoion at the single cell level: A computational approach to analyse ifish spots in consecutive sections of heterogeneous neuroblastoma tumors

M. Ambros, M. Berneder, L. Fischer, M. Feuerstein, A. Hanbury, I. Ambros, P. Ambros, S. Taschner-Mandl. Spot detectoion at the single cell level: A computational approach to analyse ifish spots in consecutive sections of heterogeneous neuroblastoma tumors. pages Poster, 6, 2019.

Autoren
  • Magdalena Ambros
  • Maria Berneder
  • Lukas Fischer
  • Marco Feuerstein
  • Allan Hanbury
  • Inge M. Ambros
  • Peter F. Ambros
  • Sabine Taschner-Mandl
TypSonstiges
Monat6
Jahr2019
SeitenPoster
Abstract

Interphase-fluorescence in situ hybridization (iFISH) is a robust and powerful method to detect chromosomal aberrations and rearrangements at single-cell resolution. Automated image analysis methods, based on iFISH spot detection at the single cell level, could help to better describe tumor heterogeneity. However, methods to segment spot- and nuclear images and to analyze spatially resolved single-cell features in tissue sections are still missing.